1-[(1,1-Imethylethoxy)Carbonyl]-3-Pyrrolidineacetic Acid Methyl Ester
Methyl 1-Boc-3-pyrrolidine acetate
CAS: 890849-27-1
Molecular Formula: C12H21NO4
1-[(1,1-Imethylethoxy)Carbonyl]-3-Pyrrolidineacetic Acid Methyl Ester - Names and Identifiers
1-[(1,1-Imethylethoxy)Carbonyl]-3-Pyrrolidineacetic Acid Methyl Ester - Physico-chemical Properties
| Molecular Formula | C12H21NO4 |
| Molar Mass | 243.3 |
| Storage Condition | 2-8°C |
1-[(1,1-Imethylethoxy)Carbonyl]-3-Pyrrolidineacetic Acid Methyl Ester - Introduction
Methyl 1-Boc-3-pyrolidine acetate is an organic compound with the chemical formula C12H21NO4. It is a colorless liquid, insoluble in water at room temperature, but soluble in non-polar solvents such as ethers, alcohols and benzene.
Methyl 1-Boc-3-Pyrrolidine acetate is usually used as a protecting group compound in organic synthesis. It can be protected from attack or denaturation in the reaction by protecting the amino group in the amine group or the nitrogen atom of the imidazole group. In addition, it can also be used to inhibit the acid sensitivity of amine and imidazole groups.
This compound can be synthesized by the following steps: First, a trimethylchlorosilane solution is added dropwise to 4-amino-1-tert-butoxycarbonylpyrrolidine to obtain methyl N-tert-butoxycarbonyl-4-(trimethylsilyl) pyrrolidine acetate. This compound is then reacted with acetic acid to give the final product Methyl 1-Boc-3-pyrolidine acetate.
Regarding safety information, the toxicity of Methyl 1-Boc-3-yrrolidine acetate is relatively small, but it should still be operated under suitable laboratory conditions. It may have an irritating effect on the lungs and skin, and has a certain toxicity. Therefore, when using or handling, wear appropriate personal protective equipment to avoid contact with skin, inhalation or ingestion. In addition, avoid contact with strong oxidants and store in a closed container, away from fire sources and high temperatures. If necessary, it should be used and handled under professional guidance.
Methyl 1-Boc-3-Pyrrolidine acetate is usually used as a protecting group compound in organic synthesis. It can be protected from attack or denaturation in the reaction by protecting the amino group in the amine group or the nitrogen atom of the imidazole group. In addition, it can also be used to inhibit the acid sensitivity of amine and imidazole groups.
This compound can be synthesized by the following steps: First, a trimethylchlorosilane solution is added dropwise to 4-amino-1-tert-butoxycarbonylpyrrolidine to obtain methyl N-tert-butoxycarbonyl-4-(trimethylsilyl) pyrrolidine acetate. This compound is then reacted with acetic acid to give the final product Methyl 1-Boc-3-pyrolidine acetate.
Regarding safety information, the toxicity of Methyl 1-Boc-3-yrrolidine acetate is relatively small, but it should still be operated under suitable laboratory conditions. It may have an irritating effect on the lungs and skin, and has a certain toxicity. Therefore, when using or handling, wear appropriate personal protective equipment to avoid contact with skin, inhalation or ingestion. In addition, avoid contact with strong oxidants and store in a closed container, away from fire sources and high temperatures. If necessary, it should be used and handled under professional guidance.
Last Update：2024-04-10 22:29:15
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CAS: 890849-27-1
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CAS: 890849-27-1
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
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